Dmitriy G. Mazhukin, Ph.D.

Secretary on Scientific Affairs NIOCH SB RAS
Born in 1962 in Vyscnii Voloshyok, Tver' Regione, USSR
Education and scientific degree:
  • 1984 Graduated from Novosibirsk State University, Department of Chemistry

Professional appointments:
    Apponiments in Novosibirsk Institute of Organic Chemistry:
  • 1984-1986 Probationer at the Laboratory of Nitrogenous Compounds, Novosibirsk Institute of Organic Chemistry(NIOCh)
  • 1986-1995 Junior researcher, Laboratory Nitrogenous Compounds, NIOCH SB RAS
  • 1995-2002 Researcher, Laboratory Nitrogenous Compounds, NIOCH SB RAS
  • Sience 2002 Secretary of Academic Council NIOCH
    Apponiments in Novosibirsk State University:
  • 1996-1999 Assistant Lecturer, Departament of Organic Chemistry, Department of Natural Sciences, Novosibirsk State University
  • 1999-2002 Senior Lecturer, Chair of Organic Chemystry, Department of Natural Sciences, Novosibirsk State University
  • Since 2002 Associate Professor, Chair of Organic Chemystry, Department of Natural Sciences, Novosibirsk State University

Honours, Awards, Fellowships
  • 1984 The first prize on the All-Union Students Conference, Novosibirsk State University
  • 2005 Assotiate Proffessor(Academic Status) in Organic Chemistry

Fields of scientific interest:
    His Professional qualifications are in synthesis organic chemistry, especially of nitrogen heterocycles. He is dealing with the design of open-chain bi- and polifunctional nitrogen bases and involvement of the latter in specific condensations and cyclizations leading to the functional N,O-containing heterocycles.
  • Stereoselective synthesis including stereospecific reduction.
  • Metalloorganic syntsis
  • Preparation of new types of chelating ligands (especially paramagnetic and those are useful for synthesis of complexes with transition metals having ferromagnetic properties)
  • Directed synthesis of biologically active heterocycles

Publications:
  1. Dulepova N.V., Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B.
    Obrazovanie proizvidnykh 2-imidazolina pri vzaimodejstvii 1,2-gidroksiaminooksimov s fenil- i metilglioksalyami
    Khimiya Geterotsiklicheskikh soedinenij, ¹ 8, 1986, s. 1060-1064, (Rus).
  2. Lebedeva E.I., Kirilyuk I.A., Mazhukin D.G.
    Atlas spektrov aromaticheskikh i geterotsiklicheskikh soedinenij. Vyp. 39. Spektry pogloshcheniya oksimov, gidroksilaminov, nitronov i geterotsiklicheskikh N-okisej v infrakrasnoj, ultrafioletovoj i vidimoj oblastyakh.
    Novosibirsk, rotaprint NIOCH SO RAN. - 1989. - 145 s., (Rus).
  3. Volodarsky L.B., Mazhukin D.G., Tikhonov A. Ya., Tikhonova L.A.
    Sposob polucheniya 1,2-bisgidroksilaminov.
    Avt. svid. ¹ 1490899. -Otkr. Izobr., ¹ 39, 1991, s. 248, (Rus).
  4. Mazhukin D.G., Volodarskii L.B., Tikhonova L.A., Tikhonov A.Ya.
    Synthesis of 3,4-Dihydro-1,2-diazete 1,2-Dioxides Based on 1,2-Bishydroxylamines and 1,2-Nitroso Oxime.
    Mendeleev Commun., - ¹ 1, V. 2, 1992, p. 29 - 30.
  5. Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B., Konovalova E.P., Tikhonova L.A., Bagryanskaya I.Yu., Gatilov Yu.V.
    Sintez alifaticheskikh 1,2-bisgidroksilaminov iz 1,3-digidroksiimidazolidinov. Kristallicheskaya struktura 1,2-bisgidroksiaminotsikloalkanov.
    Izvestiya AN. Ser. Khim., ¹ 5, 1993, s. 896 - 901, (Rus).
  6. Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B., Konovalova E.P.
    Vzaimodejstvie 1,2-bisgidroksilaminov s 1,2-dikarbonil'nymi soedineniyami. Polucheniye i svojstva 2,3-digidropirazin-1,4-dioksidov.
    Khimiya Geterotsiklicheskikh soedinenij, ¹ 4, 1993, s. 514 - 522, (Rus).
  7. Severina I.A., Ryaposova I.K., Volodarsky L.B., Mazhukin D.G., Tikhonov A.Ya., Schwartz G.Ya., et al.
    Derivatives of 1,2-Diazetine-1,2-di-N-oxides - a New Class of Soluble Guanylate Cyclase Activators with Vasodilatory Properties.
    Biochem. and Mol. Biol. Int., ¹ 2, V. 30, 1993, p. 357 -366.
  8. Schwartz G.Ya., Grigor'ev I.B., Severina I.S., Ryaposova I.K., Lapitskaya A.S., Volodarsky L.B., Tikhonov A.Ya., Kurbnikova I.F., Mazhukin D.G., Granik V.G.
    Proizvodnye 1,2-diazetin-1,2-dioksida - novyj klass generatorov oksida azota, obladayushchikh sosudorasshiryayushchej aktivnost'yu.
    Khim. - farm. zhurnal, ¹ 4, Ò. 28, 1994, s. 38-42, (Rus).
  9. Mazhukin D.G., Tikhonov A. Ya., Volodarsky L. B., Evlampieva N. P., Vetchinov V. P., Mamatyuk V. I.
    Synthesis of Indeno[1,2-b]pyrazine N-Oxides by Reaction of Ninhydrin with 1,2-Bishydroxylamines.
    Liebigs Ann. Chem., ¹ 10, 1994, p. 983 - 987.
  10. Utepbergenov D.I., Khramtsov V.V., Vlassenko L.P., Markel A.L., Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B.
    Kinetics of Nitric Oxide Liberation by 3,4-Dihydro-1,2-diazete 1,2-Dioxides and their Vasodilatory Properties in Vitro and in Vivo.
    Biochem. Biophys. Res. Commun., ¹ 3, V. 214, 1995, p. 1023-1032.
  11. Mazhukin D.G., Khlestlin V.K., Tikhonov A.Ya., Volodarsky L.B.
    Sintez 1,2-bis(metoksiamino)tsikloalkanov iz alitsiklicheskikh 1,2-bis(gidroksiaminov).
    Izv. AN. Ser. Khim., ¹ 4, 1996, s. 925-929, (Rus).
  12. Khlestkin V.K., Mazhukin D.G., Tikhonov A.Ya., Bagryanskaya I.Yu., Gatilov Yu.V., Utepbergenov D.I. et al.
    Unexpected Transformation of 1,2-Bis(N-methoxy-N-nitrosoamino)cycloalkanes: First Synthesis of 4,5-Dihydro-1,2,3-triazole 2-Oxides.
    Tetrahedron Lett., ¹ 33, V. 37, 1996, p. 5997-6000.
  13. Khramtsov V.V., Utepbergenov D.I., Voldman Ya.Yu., Vlassenko L.P., Markel' A.L., Kirilyuk I.A., Grigor'ev I.A., Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B.
    Issledovaniya in vitro i in vivo proizvodnykh 1,2-diazetina i nitronilnitroksidov v kachestve donorov i aktseptorov oksida azota.
    Biokhimiya, ¹ 10, Ò. 61., 1996, s. 1731-1742, (Rus).
  14. Dultseva G.G., Skubnevskaya G.I., Tikhonov A.Ya., Mazhukin D.G., Volodarsky L.B.
    Derivatives of Dihydro pyrazine 1,4-Dioxide, 3-Imidazoline 3-Oxide, and a-Phenyl Nitrones with Functional Groups as New Spin Traps in Solution and in the Gas Phase.
    J. Phys. Chem., ¹ 44, V. 100, 1996, P. 17523-17527.
  15. Khlestkin V.K., Reznikov V.A., Mazhukin D.G., Tikhonov A.Ya., Volodarsky L.B.
    Reaction of N-(1-Cyano-1-methylethyl)-a-phenylnitrone with Phenyl-, 2-Pyridyl- and 2-Thienylmagnesium Bromides: a New Approach to Alkylaromatic a-Hydroxylaminoketones.
    Mendeleev Commun., ¹ 5, V. 6, 1996, p. 202 - 203.
  16. Mazhukin D.G., Tikhonov A.Ya., Petrenko O.P., Volodarsky L.B.
    Neozhidannoe obrazovanie zameshchennogo furazano[3,4-d]piridazintrioksida iz a-gidroksilaminoaldoksima i ego fotokhimicheskoe prevrashcheniye v nitroksilnyj radikal pyada pirrolidina.
    Khimiya Geterotsiklicheskikh soedinenij, ¹ 3, 1997, s. 403-405, (Rus).
  17. Ovcharenko V., Korobkov I., Fokin S., Burdukov A., Romanenko G., Mazhukin D., Reznikov V. et. al.
    Complexes with Nitroxides Containing Different Substituents in the a-Position to N-O Group. The Competition of Basicity and Sterical Availability of the Donor Functions of Nitroxides in Metal Complexes with Sterically Hindered Imidazolines.
    Mol. Cryst. Liq. Cryst., V. 305, 1997, p. 311-319.
  18. Kirilyuk I.A., Utepbergenov D.I., Mazhukin D.G., Fechner K., Mertsch K., Khramtsov V.V. et al.
    Thiol-Induced Nitric Oxide Release from 3-Halogeno-3,4-dihydrodiazete 1,2-Dioxides.
    J. Med. Chem., ¹ 7, V. 41, 1998, p. 1027-1033.
  19. Bagryanskaya I.Yu., Rybalova T.V., Gatilov Yu.V., Khlestkin V.K., Mazhukin D.G.
    The First X-Ray Study of Alkoxynitrosoamines
    Acta Crystallogr. (Sect. C), ¹ 12, V. 54, 1998, IUC9800073
  20. Repinskaya I.B., Koltunov K.Yu., Mazhukin D.G.
    Spravochnyje materialy po kursu organicheskoj khimii. Varianty kontrol'nykh rabot. (Kurs 2, semestr 3. Otdeleniye «biologiya i medbiologiya»)
    Novosibirsk, 1998. – Novosibirskij Gosudarstvennyj Universitet, (Rus).
  21. Tikhonov A.Ya., Mazhukin D.G., Grigor’eva L.N., Khlestkin V.K., Voinova N.N., Syropyatov B.Ya. et al.
    Synthesis and Inhibitory Effect on Platelet Aggregation and Antihypertensive Activity of 1-Hydroxy-2,5-dihydro-1H-imidazole-2-carboxylic Acid 3-Oxides, 1,3-Dihydroxyimidazolidine 2-carboxylic Acids and 1,4-Dihydroxy-2,3-piperazinediones.
    Arch. Pharm. – Pharm Med. Chem., ¹ 9, V. 332, 1999, p. 305-308.
  22. Khlestkin V.K., Mazhukin D.G., Tikhonov A.Ya., Rybalova T.V., Bagryanskaya I.Yu., Gatilov Yu.V.
    Intramolecular Cyclization of 1,2-Bis(N-alkoxy-N-nitrosoamino)alkanes: the Unique Route to 4,5-Dihydro-1,2,3-triazole 2-Oxides.
    Synthesis., ¹ 5, 2000, p. 681-690.
  23. Mazhukin D.G., Tikhonov A.Ya., Reznikov V.A., Volodarsky L.B.
    Formation of cyclic ketene N-hydroxyaminals - 2-acyl-methylene-1-hydroxyimidazolidines in the reaction of 1,2-bishydroxylamines with 1,3-ketoaldehydes.
    Mendeleev Commun., ¹ 2, V. 10, 2000, p. 69 - 71.
  24. Khlestkin V.K., Mazhukin D.G.
    N,O-Dialkyhydroxylamines in modern organic syntheses.
    Curr. Org. Chem., ¹ 10, V. 7 , 2003, p. 967-993.
  25. Elinova V.I., Bobko A.A., Mazhukin D.G., Markel' A.G., Khramtsov V.V.
    Novye donory i aktseptory NO kak potentsial'nyje terapevticheskiye agenty.
    Bioorganicheskaya khimiya, ¹ 4, Ò. 29, 2003, s. 434 -441, (Rus).
  26. Reznikov V.A., Roshchupkina G.I., Mazhukin D.G., Petrov P.A., Popov S.A., Fokin S.V. et al.
    A new class of enehydroxylamino ketones: (R)-2-(1-hydroxy-4,4,5,5-tetraalkylimidazolidin-2-ylidene)ethanones: Synthesis and reactions.
    Eur. J. Org. Chem., ¹ 4, 2004, p. 749 – 765.
  27. Butakov V.V., Khlestkin V.K., Mazhukin D.G.
    Formation of N,N’-dihydroxy- and N,N’-dimethoxy-1,4-diazepine derivatives in the reaction of 1,2-bis(hydroxyamines) and 1,2-bis(methoxyamine) with enone Mannich bases.
    Mendeleev Commun., ¹ 4, V. 15, 2005, p. 162 - 163.